12/7/2023 0 Comments Gabrielle ludwig![]() Sun X, Yang LV, Tiegs BC et al (2010) Deletion of the pH sensor GPR4 decreases renal acid excretion. ![]() Seuwen K, Ludwig MG, Wolf RM (2006) Receptors for protons or lipid messengers or both? J Recept Signal Transduct Res 26:599–610 Sanderlin EJ, Marie M, Velcicky J et al (2019) Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model. Parry DA, Smith CE, El-Sayed W et al (2016) Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta. Onozawa Y, Fujita Y, Kuwabara H et al (2012) Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro. Okajima F (2013) Regulation of inflammation by extracellular acidification and proton-sensing GPCRs. Ma XD, Hang LH, Shao DH et al (2017) TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Ludwig MG, Vanek M, Guerini D et al (2003) Proton-sensing G-protein-coupled receptors. Liu JP, Nakakura T, Tomura H et al (2010) Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways. Lassen KG, McKenzie CI, Mari M et al (2016) Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk. Kumar NN, Velic A, Soliz J et al (2015) Regulation of breathing by CO 2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Krieger NS, Yao Z, Kyker-Snowman K et al (2016) Increased bone density in mice lacking the proton receptor OGR1. Justus CR, Dong L, Yang LV (2013) Acidic tumor microenvironment and pH-sensing G protein-coupled receptors. Jostins L, Ripke S, Weersma RK et al (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Hutter S, van Haaften WT, Hünerwadel A et al (2018) Intestinal activation of pH-sensing receptor OGR1 contributes to fibrogenesis. Huang XP, Karpiak J, Kroeze WK et al (2015) Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Pharmacol Res Perspect 7:e00542įukuda H, Ito S, Watari K et al (2016) Identification of a potent and selective GPR4 antagonist as a drug lead for the treatment of myocardial infarction. Front Physiol 4:370įoster JR, Ueno S, Chen MX et al (2019) N-palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132. ![]() Damaghi M, Wojtkowiak JW, Gillies RJ (2013) pH sensing and regulation in cancer.
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